HuagongsheHuagongshe Chemistry Print Report · For research reference only
Naphthalic anhydride, 3-nitro- → 2-Tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Naphthalic anhydride, 3-nitro- | HCID 18194 | — |
| Reactant | O-(tert-Butyldimethylsilyl)hydroxylamine | HCID 4691350 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Tert-butyldimethylsilyoxy-5-nitro-benzo[de]isoquinoline-1,3-dione | HCID 131722278 | 85.1% |
Reaction Steps
O-(tert-Butyldimethyl-silyl) hydroxylamine (1.8 g, 12.3 mmol) was added to a solution of 3-nitro-1,8-naphthalic anhydride (2.0 g, 8.2 mmol) in 50 mL of pyridine. The solution was refluxed for 4 hours and concentrated in vacuo. Purification as described in Example A-1 gave 2.6 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362181B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-3ee34f4dcba04f1fa67a595b72196c40 |
| Source note | uspto-grants-2002_03 |