反应详情

O-Benzyl hydroxylamine hydrochloride (0.8 g, 6.5 mmol) was added to a suspension of 3-nitro-1,8-naphthalic anhydride (1.0 g, 4.1 mmol) in pyridine (20 mL). The mixture was refluxed for 3 hours and concentrated in vacuo. The solid residue obtained was purified by column chromatography (silica gel using 2% methanol in chloroform). Fractions containing the target compound were combined, concentrated, and dried to give 1.3 g of the title compound, mp 239-241° C.;

1. temperatureThe mixture was refluxed for 3 hours
2. concentrationconcentrated in vacuo
3. customThe solid residue obtained
4. customwas purified by column chromatography (silica gel using 2% methanol in chloroform)
5. additionFractions containing the target compound
6. concentrationconcentrated
7. customdried