2-Benzyloxy-5-bromo-benzo[de]isoquinoline-1,3-dione → 2-Benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione

Participants

Reaction Steps

Dimethylzinc (4 mL, 2 eq.) was added to a suspension of 2-benzyloxy-5-bromo-benzo[de]isoquinoline-1,3-dione (1.5 g, 3.9 mmol, from Example O) and Pd(PPh3)2Cl2 (0.14 g, 0.2 mmol) in dry THF (20 mL). The mixture was stirred under nitrogen at room temperature for 8 hours, filtered, and washed with dimethylacetamide. Concentration of the filtrate gave 1.1 g of the title compound in crude form which was used as is.

Provenance & Evidence