HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 278975Generated: October 30, 2026
Dimethylacetamide → [1-(2-tert-butyloxy-2,3-dihydro-1,3-dioxo-1H-benzo[de]isoquinolin-6-yl)-pyrrolidin-3-yl]-carbamic acid, tert-butyl ester
https://huagongshe.com/reaction/278975
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Tert-butyl 1-aminopyrrolidine-3-carboxylate | HCID 21876723 | — |
| Reactant | 6-Bromo-2-tert-butyloxy-benzo[de]isoquinoline-1,3-dione | HCID 22623954 | — |
| Product | [1-(2-tert-butyloxy-2,3-dihydro-1,3-dioxo-1H-benzo[de]isoquinolin-6-yl)-pyrrolidin-3-yl]-carbamic acid, tert-butyl ester | HCID 131722279 | — |
Reaction Steps
A mixture of 6-bromo-2-tert-butyloxy-2,3-dihydro-1H-benzo[de]isoquinoline-1,3-dione (0.5 g, 1.4 mmol, from Example K2) and 3-Boc-aminopyrrolidine (0.8 g, 4.7 mmol) in DMA (4.0 mL) was heated at 120° C. overnight. The mixture was concentrated, and water was added to give a precipitate, which was filtered to yield 0.6 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06362181B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-253a79e466da4dd2bd3a0307ef8ef9fd |
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| Source note | uspto-grants-2002_03 |
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