反应详情

To a suspension of 620 mg (2.9 mmol) of 4-hydroxy-1,8-naphthalic anhydride (from Example S3) and 1.60 g (53.0 mmol) of paraformaldehyde in 20 mL dioxane was added 5.2 mL of concentrated sulfuric acid. The reaction mixture was refluxed for 1 hour and quenched with 100 mL water. The precipitate was isolated, dried, recrystallized from DMSO, washed with acetone, and dried again to yield 0.50 g of the title compound.

1. temperatureThe reaction mixture was refluxed for 1 hour
2. customquenched with 100 mL water
3. customThe precipitate was isolated
4. customdried
5. customrecrystallized from DMSO
6. washwashed with acetone
7. customdried again