HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitro-1,8-naphthalic anhydride → 2-Hydroxy-6-nitro-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitro-1,8-naphthalic anhydride | HCID 81150 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-Hydroxy-6-nitro-benzo[de]isoquinoline-1,3-dione | HCID 819865 | 72.4% |
Reaction Steps
4-Nitro-1,8-naphthalic anhydride (2.61 g, 10.7 mmol) and hydroxylamine hydrochloride (1.5 g, 21.4 mmol) were reacted in pyridine (50 mL) following the procedure of Example 1. The crude product was recrystallized from ethanol to give 2.0 g of the title compound, mp 255-260° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362181B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-44708f525f254901ae63a395fb1890ca |
| Source note | uspto-grants-2002_03 |