HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H,3H-Naphtho(1,8-cd)pyran-1,3-dione, 6-bromo- → 6-bromo-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H,3H-Naphtho(1,8-cd)pyran-1,3-dione, 6-bromo- | HCID 66493 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 6-bromo-2-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione | HCID 708429 | 82.6% |
Reaction Steps
4-Bromo-1,8-naphthalic anhydride (1.6 g, 5.8 mmol) and hydroxylamine hydrochloride (0.8 g, 11.5 mmol) were reacted in pyridine (30 mL) following the procedure of Example 1 to give 1.4 g of the title compound, mp 248-251 ° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362181B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-a4e31146847a4702a07195a452290673 |
| Source note | uspto-grants-2002_03 |