N-bromobutanimide → HCID 22623953, compound

HRID 279006Notes

Reaction equation

HRID 279006 reaction equation
[OH:1][N:2]1[C:11](=[O:12])[C:10]2[CH:13]=[C:14]([O:16][CH3:17])[CH:15]=[C:8]3[C:9]=2[C:4](=[CH:5][CH:6]=[CH:7]3)[C:3]1=[O:18].[Br:19]N1C(=O)CCC1=O>C(O)(=O)C>[Br:19][C:15]1[C:14]([O:16][CH3:17])=[CH:13][C:10]2[C:11](=[O:12])[N:2]([OH:1])[C:3](=[O:18])[C:4]3[C:9]=2[C:8]=1[CH:7]=[CH:6][CH:5]=3

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 708421HCID 708421, compound

Product 1

HCID 22623953HCID 22623953, compoundYield 26.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Hydroxy-5-methoxy-benzo[de]isoquinoline-1,3-dione (0.32 g, 1.3 mmol, from Example 13) and N-bromosuccinimide (0.33 g, 1.8 mmol) were reacted in acetic acid (10 mL) following the procedure of Example 31 to give 0.11 g of the title compound, mp 250-253° C.;

Sources & evidence

ORD record
ord-23e38b3ed5f040cd833cfc42d3073ed5
Source dataset
uspto-grants-2002_03
Patent number
US06362181B1

Reaction notes

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