HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-6-(3-Amino-pyrrolidin-1-yl)-5-cyano-2-hydroxy-benzo[de] isoquinoline-1,3-dione, Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-[1-(5-cyano-2-hydroxy-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)-pyrrolidin-3-yl]-carbamic acid, tert-butyl ester | HCID 86756249 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-6-(3-Amino-pyrrolidin-1-yl)-5-cyano-2-hydroxy-benzo[de] isoquinoline-1,3-dione, Hydrochloride | HCID 131722282 | — |
Reaction Steps
The (S)-[1-(5-cyano-2-hydroxy-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)-pyrrolidin-3-yl]-carbamic acid, tert-butyl ester from above was dissolved in EtOH and reacted with a stream of HCl gas forming a precipitate which was collected by filtration and dried to give 0.021 g of the title compound, mp >250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362181B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-8779897a7d8b4146bf770cdd359cfa73 |
| Source note | uspto-grants-2002_03 |