Phenylsilane → HCID 22623987, compound

Participants

Reaction Steps

To a 0° C. solution of 2-allyloxy-5-bromo-7-(pyrrolidin-1-yl)-benzo[de]isoquinoline-1,3-dione (0.81 g, 2.0 mmol, from Example G2) in CH2Cl2 (40 mL) was added phenylsilane (0.32 g, 3.0 mmol) and Pd(PPh3)4 (0.050 g, 0.043 mmol). The reaction was stirred for 15 minutes, and the resulting precipitate removed by filtration, washed with CH2Cl2, and dried to give 0.60 g of the title compound, mp 234-235° C.

Provenance & Evidence