Trifluoroacetic acid → 5-Chloro-2-hydroxy-6-[3-methoxypyrrolidin-1-yl]-benzo[de]isoquinoline-1,3-dione

Participants

Reaction Steps

Following the procedure from Example 62, TFA (1.0 mL) and 2-tert-butyloxy-5-chloro-6-[3-methoxypyrrolidin-1-yl]-benzo[de]isoquinoline-1,3-dione (0.2 g, 0.5 mmol, from Example S2) was stirred at room temperature overnight, concentrated, and the solid recrystallized from ethanol/ether solution to give 0.02 of the title compound, mp 136-142° C.

Provenance & Evidence