Sodium Hydroxide → HCID 22623944, compound

Participants

Reaction Steps

A suspension of 4-acetylamino-7-chloro-2-hydroxy-6-(pyrrolidin-1yl)benzo[de]isoquinoline-1,3-dione (0.08 g, 0.2 mmol, from Example 138), 0.5N sodium hydroxide (5 mL) and ethanol (5 mL) was heated to solution and then stirred to room temperature over 1 hour. The ethanol was evaporated in vacuo, the aqueous diluted to 15 mL with water, and acidified with acetic acid. The mixture was extracted with dichloromethane, dried, filtered, and evaporated in vacuo. The residue was triturated with ether/petroleum ether to give 0.035 g of the title compound, mp 211-213° C.

Provenance & Evidence