Sodium periodate → HCID 70169858, compound

Participants

Reaction Steps

A solution of sodium periodate (0.067 g. 0.313 mM) in water (2.5 ml) was added to a stirred suspension of the title product from Example 37 (0.12 g. 0.283 mM) in MeOH (10 ml) and the mixture heated at gentle reflux for 3 hours. The mixture was filtered hot and allowed to cool. The solid which precipitated was filtered, washed with water and ether and purified by chromatography on a BondElut silica column with gradient elution increasing in polarity from dichloromethane to 10% MeOH/dichloromethane to give the title compound (0.07 g). MS: 441 (MH+); NMR 1.83 (3H, s); 2.9 (3H, s); 3.45 (2H, t); 3.83 (1H, m); 4.2 (1H, t); 4.75 (1H, m); 7.75 (2H, d) 7.9 (1H, m); 7.96 (2H; d); 8.05 (1H, d); 8.24 (1H, t); 8.36 (1H, s); 9.83 (1H, s).

Provenance & Evidence