Hydrochloric Acid → HCID 69720667, compound

Participants

Reaction Conditions

Reaction Steps

2-Acetyl-1-indanone (15 g, cf. Liebigs Ann. Chem. 347 (1906) 112) was added into a mixture of potassium carbonate (8.5 g) and dry N,N-dimethylformamide (45 ml). The mixture was stirred at 50-55° C. for 20 minutes and ethyl 3-bromopropionate (19 g) was then added and the stirring was continued at 50-55° C. for 6 hours. Water (60 ml) was added to the reaction mixture and the pH of the solution was adjusted to 2-3 with hydrochloric acid. The mixture was stirred at 50-55° C. for one hour. The cooled solution was extracted with toluene, washed with water, dried with sodium sulfate, and the solvent removed under reduced pressure. The yield was 23.5 g.

Provenance & Evidence