Water → HCID 178515457, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 8a-(1H-imidazol-4-yl)-1,3a,8,8a-tetrahydro-2H-cyclopenta[a]inden-3-one (1 g) in 40 ml of ethanol was added 0.16 g of sodium borohydride under a nitrogen atmosphere. The reaction mixture was stirred at 35-40° C. for 4 hours and then poured into water (100 ml) and extracted with methylene chloride (3×100 ml). The combined organic layers were dried over sodium sulfate and the solvent removed under reduced pressure. The crude product was purified by flash chromatography using methylene chloride/methanol (95:5) as eluent. The yield was 0.6 g, m.p. 183-186° C.

Provenance & Evidence