HCID 178418361, compound → HCID 178422492, compound

HRID 279141Notes

Reaction equation

HRID 279141 reaction equation
[CH2:1]=[C:2]1[CH:6]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C:5]2([C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)[CH2:4][CH2:3]1.[H][H]>C(O)C.[Pd]>[CH3:1][CH:2]1[CH:6]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[CH2:13][C:5]2([C:14]2[N:15]=[CH:16][NH:17][CH:18]=2)[CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178422491HCID 178422491, compound

Product 1

HCID 178422492HCID 178422492, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-(3-Methylene-2,3,3a,8-tetrahydro-1H-cyclopenta[a]inden-8a-yl)-1H-imidazole (0.23 g) was dissolved in 20 ml of ethanol and the mixture was hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst until no more hydrogen was consumed. The catalyst was filtered off and the solvent removed under reduced pressure. The residue was crystallized from ethyl acetate. The yield was 0.14 g, m.p. 168-172° C.

Workup

  1. customwas consumed
  2. filtrationThe catalyst was filtered off
  3. customthe solvent removed under reduced pressure
  4. customThe residue was crystallized from ethyl acetate

Sources & evidence

ORD record
ord-38d47e635e854ed29442d596f03d74e4
Source dataset
uspto-grants-2002_03
Patent number
US06362211B1

Reaction notes

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