反应详情

(1-Bromocyclohexyl)phenyl ketone (14.1 g) was dissolved in pyridine (60 ml) and the mixture was refluxed for 1 hour. After cooling to the ambient temperature the mixture was filtered and evaporated. The residue was dissolved in CH2Cl2 (50 ml) and extracted with 1 M HCl (2×30 ml) and water (30 ml). The organic layer was dried over Na2SO4 and evaporated. Yield was 9.7 g.

1. temperaturethe mixture was refluxed for 1 hour
2. filtrationwas filtered
3. customevaporated
4. dissolutionThe residue was dissolved in CH2Cl2 (50 ml)
5. extractionextracted with 1 M HCl (2×30 ml) and water (30 ml)
6. dry with materialThe organic layer was dried over Na2SO4
7. customevaporated