2,2-Diethoxyethylamine → 1-(2,2-diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea

HRID 279169Notes

Reaction equation

[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:21])OC3C=CC=CC=3)=[CH:8][CH:7]=2)[CH:5]=[N:4][CH:3]=[N:2]1.[CH2:22]([O:24][CH:25]([O:28][CH2:29][CH3:30])[CH2:26][NH2:27])[CH3:23]>N1C=CC=CC=1>[CH2:22]([O:24][CH:25]([O:28][CH2:29][CH3:30])[CH2:26][NH:27][C:13]([NH:12][C:9]1[CH:8]=[CH:7][C:6]([N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:11][CH:10]=1)=[O:21])[CH3:23]

Participants

Conditions

Temperature: 50 °C

Procedure

A mixture of phenyl 4-(1H-1,2,4-triazol-1-yl)phenylcarbamate (13 g), 2,2-diethoxyethyl amine (7.4 g) and pyridine (3.67 g) was heated at 50° C. for 3 hours. The resultant was cooled and the precipitated crystals were washed with a mixture of diisopropyl ether and petroleum ether (1:1, 100 ml×2) to give 1-(2,2-diethoxyethyl)-3-[4-(1H-1,2,4-triazol-1-yl)phenyl]urea (14.5 g) as a colorless crystalline powder.

Workup

temperatureThe resultant was cooled
washthe precipitated crystals were washed with a mixture of diisopropyl ether and petroleum ether (1:1, 100 ml×2)

Sources & evidence

ORD record: ord-a47e9508c36c4e499532309fc821b046
Source dataset: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06362206B1

Reaction notes

Loading…