Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 10154224, compound

Participants

Reaction Conditions

Reaction Steps

(2S)-2′-Fluoro-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (25 g) was dissolved in ethanol (200 ml), to which pyridinium p-toluenesulfonate (1.28 g) was added. The reaction solution was stirred at 55° C. for 2.5 hours and then concentrated. The residue was subjected to silica gel chromatography (eluent: hexane/ethyl acetate=9/1 to 5/1) to give (2S)-2′-fluoro-2-hydroxypropiophenone (16.4 g) as a colorless oily substance.

Provenance & Evidence