1-(7-Indolecarbonyl)-3-(R)-(4-(4fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine → 1-(N-Allyl-7-indolecarbonyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine

HRID 279223Notes

Reaction equation

HRID 279223 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[N:11]([CH2:13][CH:14]=[CH2:15])[CH:10]=[CH:9]2)([OH:3])=O.N1C2C(=CC=CC=2C([N:27]2[CH2:31][C@@H:30]([CH:32]3[CH2:34][CH2:33]3)[C@H:29]([CH2:35][N:36]3[CH2:41][CH2:40][CH:39]([C:42]4[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=4)[CH2:38][CH2:37]3)[CH2:28]2)=O)C=C1>>[CH2:13]([N:11]1[C:12]2[C:8](=[CH:7][CH:6]=[CH:5][C:4]=2[C:1]([N:27]2[CH2:31][C@@H:30]([CH:32]3[CH2:33][CH2:34]3)[C@H:29]([CH2:35][N:36]3[CH2:37][CH2:38][CH:39]([C:42]4[CH:43]=[CH:44][C:45]([F:48])=[CH:46][CH:47]=4)[CH2:40][CH2:41]3)[CH2:28]2)=[O:3])[CH:9]=[CH:10]1)[CH:14]=[CH2:15]

Participants

3

Reactant 2

HCID 187135121-(7-Indolecarbonyl)-3-(R)-(4-(4fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidineHCID 226244697-carboxy-N-allylindole

Product 1

HCID 187135181-(N-Allyl-7-indolecarbonyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine

Procedure

The title compound was prepared from 7-carboxy-N-allylindole and 3-(S)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine (Example 11) as described in Example 11. Mass Spectrum (EI) m/e 486 (M+1).

Sources & evidence

ORD record
ord-c3f9271c89af49cdbe154e1607a7d8bf
Source dataset
uspto-grants-2002_03
Patent number
US06362201B1

Reaction notes

Loading…