HRID279226

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(c1cccc2ccccc12)N1C[C@@H](CN2CCC(c3ccc(F)cc3)CC2)[C@H](C2CC2)C1

HCID18713506

未命名化合物

结构：CC(C)(C)OC(=O)NCCCn1ccc2cccc(C(=O)O)c21

HCID70163739

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NCCCn1ccc2cccc(C(=O)N3C[C@@H](CN4CCC(c5ccc(F)cc5)CC4)[C@H](C4CC4)C3)c21

HCID18713527

未命名化合物

收率 5.4%

PROCEDURE

实验过程

1-(N-(3-t-butoxycarbonylaminopropyl)-7-indolecarbonyl)-3-(R)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine (0.13 g) was prepared from 0.125 g (4 mmol) of 3-(S)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(S)-(cyclopropyl)pyrrolidine (Example 9) and 0.13 g (4.3 mmol) of 7-carboxy-N-(3-t-butoxycabonylaminopropyl)indole as described in Example 11. It was purified by chromatography (silica, acetone:hexanes, 3:7).

WORKUP

后处理

customIt was purified by chromatography (silica, acetone:hexanes, 3:7)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4f8b3de05bb4899b5f89c96aa0f7b32
来源数据集: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06362201B1
来源说明: uspto-grants-2002_03

反应 SMILES

[C:1]1([C:11]([N:13]2[CH2:17][C@@H:16]([CH:18]3[CH2:20][CH2:19]3)[C@H:15]([CH2:21][N:22]3[CH2:27][CH2:26][CH:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)[CH2:24][CH2:23]3)[CH2:14]2)=[O:12])[C:10]2[C:5](=[CH:6]C=CC=2)[CH:4]=[CH:3][CH:2]=1.C(C1C=CC=C2C=1[N:45]([CH2:47][CH2:48][CH2:49][NH:50][C:51]([O:53][C:54]([CH3:57])([CH3:56])[CH3:55])=[O:52])[CH:44]=C2)(O)=O>>[C:54]([O:53][C:51]([NH:50][CH2:49][CH2:48][CH2:47][N:45]1[C:10]2[C:5](=[CH:4][CH:3]=[CH:2][C:1]=2[C:11]([N:13]2[CH2:17][C@@H:16]([CH:18]3[CH2:20][CH2:19]3)[C@H:15]([CH2:21][N:22]3[CH2:27][CH2:26][CH:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)[CH2:24][CH2:23]3)[CH2:14]2)=[O:12])[CH:6]=[CH:44]1)=[O:52])([CH3:57])([CH3:56])[CH3:55]