HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonate → alpha-Cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | Benzeneacetonitrile, alpha-hydroxy-3-phenoxy-, (alphaS)- | HCID 93218 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | 2-(1-Benzothiophen-3-yl)-3-methylbutanoic acid | HCID 53716412 | — |
| Solvent | tetrahydrofuran N,N-dimethylformamide | HCID 21974620 | — |
| Product | alpha-Cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate | HCID 54429257 | — |
Reaction Steps
A mixture of 2-(3-benzothienyl)-3-methylbutanoic acid (3.4 mmol) and KCHO3 (3.4 mmol) on 15 ml THF/DMF (1:1) is stirred for about 15 minutes. The mesylate of α-cyano-3-phenoxybenzyl alcohol (3.4 mmol) in 5 ml THF/DMF is added and the reaction mixture stirred for about 48 hours. The reaction is worked up as in Example 2, developing with 10% ethyl acetate/hexane to yield α-cyano-3-phenoxybenzyl 2-(3-benzothienyl)-3-methylbutanoate, colorless thick liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04224330 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-62de4d5dcc5440a6a1556c6338ced5c4 |
| Source note | uspto-grants-1980_09 |