反应详情

To lithium aluminum hydride (26.5 mmol) and 50 ml ether, at -20° under nitrogen, is slowly added methyl 5-chlorobenzothiophene-2-carboxylate (6 g, 26.5 mmol). The mixture is then stirred at -20° for 10 minutes. After no starting material is detectable by thin layer chromatography, the mixture is quenched with 1 ml water, 1 ml 15% NaOH, and 3 ml water at -20°. The mixture is allowed to warm to RT and stirred for 15 hours. The mixture was then filtered and solvent evaporated to give 5-chlorobenzothiophene-2-methanol.

1. customat -20°
2. customthe mixture is quenched with 1 ml water, 1 ml 15% NaOH, and 3 ml water at -20°
3. stirringstirred for 15 hours
4. filtrationThe mixture was then filtered
5. customsolvent evaporated