HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenylacetaldehyde → 1-(4-chlorobenzyl)-4-{N-(2,2-diphenylethyl)aminomethyl}piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenylacetaldehyde | HCID 13696 | — |
| Reactant | Borohydride | HCID 28123 | — |
| Reactant | {[1-(4-Chlorobenzyl)piperidin-4-yl]methyl}amine | HCID 18426145 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-chlorobenzyl)-4-{N-(2,2-diphenylethyl)aminomethyl}piperidine | HCID 18426158 | 49% |
Reaction Steps
Reductive amination of 4-(aminomethyl)-1-(4-chlorobenzyl)piperidine (120 mg) with 2,2-diphenylacetaldehyde (0.66 equiv.) and polymer-supported borohydride in methanol at 25° C. for 16 h, followed by general workup and column chromatography (SiO2) afforded 1-(4-chlorobenzyl)-4-{N-(2,2-diphenylethyl)aminomethyl}piperidine (70 mg, 49%): The purity was determined by RPLC (98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362177B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-b18ae9a526c54caea7d2815eff3bbe4e |
| Source note | uspto-grants-2002_03 |