HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 53890501, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-2-(3-phenoxyphenyl)acetonitrile | HCID 12774587 | — |
| Reactant | 2-(5-Chloro-2-benzothienyl)-3-methylbutanoic acid | HCID 54204673 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53890501 | HCID 53890501 | — |
Reaction Steps
A mixture of 10 ml methylene chloride, 10 ml THF, 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid (0.5 g), K2CO3 (0.25 g) and α-cyano-3-phenoxybenzyl chloride (0.42 g) is stirred at RT for 15 hours. Then 5 ml of DMSO is added and reaction mixture stirred for about 48 hours. The mixture is taken up in ether, washed with water and brine, dried over Na2SO4 and solvent removed. The crude product is plated developing with 10% ethyl acetate/hexane to give α-cyano-3-phenoxybenzyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04224330 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-cf38697a35bb42deafa3cb060ccaab2f |
| Source note | uspto-grants-1980_09 |