HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[{N-(9fluorenylmethyloxycarbonyl)glycyl}aminomethyl]-1(4-fluorobenzyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | 4-[[N-(9-fluorenylmethyloxycarbonyl)glycyl]aminomethyl]piperidine | HCID 54359471 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-[{N-(9fluorenylmethyloxycarbonyl)glycyl}aminomethyl]-1(4-fluorobenzyl)piperidine | HCID 18426163 | — |
Reaction Steps
A solution of 4-[{N-(9-fluorenylmethyloxycarbonyl)glycyl}aminomethyl]piperidine (1.50 g, 3.49 mmol), 4-fluorobenzyl bromide (0.478 mL, 3.84 mmol), and Et3N (1.47 mL, 10.5 mmol) in CH3CN (200 mL) was stirred at room temperature for 13 h and concentrated. Column chromatography (SiO2, 10% , CH3OH/CH2Cl2) afforded 4-[{N-(9-fluorenylmethyloxycarbonyl)glycyl}aminomethyl]-1-(4-fluorobenzyl)piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362177B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-09f04aecf40a42a7bdeef6fa7d39e200 |
| Source note | uspto-grants-2002_03 |