HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → 4-{(Glycylamino)methyl)-1-(4-fluorobenzyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-[{N-(9fluorenylmethyloxycarbonyl)glycyl}aminomethyl]-1(4-fluorobenzyl)piperidine | HCID 18426163 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-{(Glycylamino)methyl)-1-(4-fluorobenzyl)piperidine | HCID 18426233 | 46% |
Reaction Steps
A solution of the 4-[{N-(9-fluorenylmethyloxycarbonyl)glycyl}aminomethyl]-1-(4-fluorobenzyl)piperidine and piperidine (5 mL) in DMF (5 mL) was stirred at room temperature for 17 h. Concentration and column chromatography (SiO2, Et3N:CH3OH:CH2Cl2=0.5:2:8) afforded 4-{(glycylamino)methyl}-1-(4-fluorobenzyl)piperidine (453 mg, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362177B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-b1de933bfc8744cfabb3a8fbb56d92c5 |
| Source note | uspto-grants-2002_03 |