Boron trifluoride etherate → HCID 22624680, compound

Participants

Reaction Steps

To a solution of 80 mg (0.23 mmol) of the material prepared in Example 1 in 2 ml of dichloromethane and 32 mg (0.28 mmol) of triethylsilane at −78° C., was added 49 mg (0.35 mmol) of boron trifluoride diethyl etherate. The mixture was stirred for 1 h., the bath was removed and stirred at ambient temperature for 30 min. A saturated solution of sodium bicarbonate (2 ml) was added and extracted with dichloromethane, dried over Na2SO4, filtered and concentrated in vacuo. Chromatography (75 g of silica gel, 25% ethyl acetate/hexane) of the residue afforded 38 mg (50%) of the title compound. Analysis calculated for C16H27NO2S2: %C, 58.32; %H, 8.26; %N, 4.25. Found: %C, 59.06; %H, 8.48; %N, 4.31. Field Desorption Mass Spectrum: M=329.

Provenance & Evidence