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Hydroxylamine → trans-4-Hepten-3-yl acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxylamine | HCID 787 | — |
| 反応物 | Tert-Butylbenzene | HCID 7366 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | (E)-2-Pentenal | HCID 5364752 | — |
| 反応物 | HCID 178418750 | HCID 178418750 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | trans-4-Hepten-3-yl acetate | HCID 22625128 | — |
反応手順
A vial was charged with aminoalcohol 1 (0.0032 g, 0.011 mmol) prepared as in Example 1. To the vial was added 1.62 mL of a stock solution containing trans-2-pentenal (0.34 g), t-butylbenzene internal standard (0.25 g), 1 M diethylzinc in hexane (8.0 mL), and toluene (4.0 mL). After 48 h, acetic anhydride (0.200 mL) was added. After an additional 72 h, a sample of the solution was analyzed by gas chromatography at 80° C. on a Cyclodex B stationary phase. The product trans4hepten-3-yl acetate was formed 85% enantiomeric excess.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06362344B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-1cc1fcedbb564f0aa8748dd9ffd9be19 |
| 出典メモ | uspto-grants-2002_03 |