HCID 21163943, compound → Cyano[6-(2-fluorophenoxy)-2-pyridyl]methyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate

HRID 27941Notes

Reaction equation

HRID 27941 reaction equation
C(C(C1C=CC=C(C2C=CC(OC)=C(OC)C=2)N=1)O)#N.[C:21]([CH:23]([C:25]1[CH:30]=[CH:29][CH:28]=[C:27]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[F:38])[N:26]=1)[OH:24])#[N:22].[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[S:47][C:46]([CH:48]([CH:52]([CH3:54])[CH3:53])[C:49]([OH:51])=[O:50])=[CH:45][C:44]=2[CH:55]=1>>[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[S:47][C:46]([CH:48]([CH:52]([CH3:53])[CH3:54])[C:49]([O-:51])=[O:50])=[CH:45][C:44]=2[CH:55]=1.[Cl:39][C:40]1[CH:41]=[CH:42][C:43]2[S:47][C:46]([CH:48]([CH:52]([CH3:53])[CH3:54])[C:49]([O:24][CH:23]([C:21]#[N:22])[C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=4[F:38])[N:26]=3)=[O:50])=[CH:45][C:44]=2[CH:55]=1

Participants

5

Reactant 3

HCID 21163943HCID 21163943, compoundHCID 542046732-(5-Chloro-2-benzothienyl)-3-methylbutanoic acidHCID 86737228Cyano [6-(3,4-dimethoxyphenyl)-2-pyridyl] methanol

Product 2

HCID 53698829Cyano[6-(2-fluorophenoxy)-2-pyridyl]methyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoateHCID 867372275-Chloro-2-benzothienyl-3-methylbutanoate

Procedure

The alcohol, cyano [6-(3,4-dimethoxyphenyl)-2-pyridyl] methanol and cyano [6-(2-fluorophenoxy)-2-pyridyl]methanol, is reacted with the acid chloride of 2-(5-chloro-2-benzothienyl)-3-methylbutanoic acid to yield cyano[6-(3,4-dimethoxy-phenoxy)-2-pyridyl]methyl 2-(5-chloro-2-benzothienyl-3-methylbutanoate and cyano[6-(2-fluorophenoxy)-2-pyridyl]methyl 2-(5-chloro-2-benzothienyl)-3-methylbutanoate.

Sources & evidence

ORD record
ord-b7f9ee29f1a54a7b8ec9bfa71b21d33a
Source dataset
uspto-grants-1980_09
Patent number
US04224330

Reaction notes

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