反应详情

At first, a 1-liter autoclave equipped with a mechanical stirrer was charged with 50 g (0.21 mol) of 3,5-bis(trifluoromethyl)benzonitrile, 200 ml of 2M-ammoniacal methanol solution (containing 400 mmol of ammonia), and 3 g of a catalyst (i.e., a carbon powder (50% wet) carrying thereon 5% palladium), followed by introduction of hydrogen to have a pressure of 1 MPa. Then, the reaction mixture was stirred, while the reaction temperature was maintained at 20° C. and while hydrogen was gradually introduced into the autoclave in a manner to maintain the total pressure at 1 MPa. After conducting the reaction for 5.3 hr, the reaction was stopped, followed by removing the catalyst by filtration. As a result of analyzing the obtained reaction liquid by gas chromatography, 3,5-bis(trifluoromethyl)benzylamine was formed at a yield of 87.0%.

1. customAt first, a 1-liter autoclave equipped with a mechanical stirrer
2. additionwas gradually introduced into the autoclave in a manner
3. temperatureto maintain the total pressure at 1 MPa
4. customthe reaction for 5.3 hr
5. customby removing the catalyst
6. filtrationby filtration
7. customAs a result
8. customthe obtained reaction liquid by gas chromatography