Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride

HRID 279496노트

반응식

HRID 279496 반응식
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13](=O)[NH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>CN(C=O)C>[ClH:24].[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([Cl:24])=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 1354047187-Benzyloxy-6-methoxy-3H-quinazolin-4-one

생성물 1

HCID 220308367-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (2.82 g, 0.01 mol), thionyl chloride (40 ml) and DMF (0.28 ml) was stirred and heated at reflux for 1 hour. The mixture was evaporated, the residue was taken up in toluene and evaporated to dryness to give 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (3.45 g).

후처리

  1. temperatureheated
  2. temperatureat reflux for 1 hour
  3. customThe mixture was evaporated
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-5b5564b2a6e2480080f50d605d1ecf66
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06362336B1

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