HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 4-(3-Acetoxy-4-methylanilino)-6-methoxy-7-(pyrimidin-4-ylmethoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 4-(Chloromethyl)pyrimidine | HCID 13123553 | — |
| Reactant | 4-(3-Acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride | HCID 135671180 | — |
| Product | 4-(3-Acetoxy-4-methylanilino)-6-methoxy-7-(pyrimidin-4-ylmethoxy)quinazoline | HCID 22625037 | 77.1% |
Reaction Steps
Using an analogous procedure to that described for the starting material in Example 1, 4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (560 mg) was reacted in the presence of catalytic potassium iodide with 4-(chloromethyl)pyrimidine (375 mg) to give 4-(3-acetoxy-4-methylanilino)-6-methoxy-7-(pyrimidin-4-ylmethoxy)quinazoline (496 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362336B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-50be9334d4ce40dbb23a88bf701372e5 |
| Source note | uspto-grants-2002_03 |