HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 4-(3-Acetoxy-4-methylanilino)-6-methoxy-7-(3-thienylmethoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 3-(Chloromethyl)thiophene | HCID 12487462 | — |
| Reactant | 4-(3-Acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride | HCID 135671180 | — |
| Product | 4-(3-Acetoxy-4-methylanilino)-6-methoxy-7-(3-thienylmethoxy)quinazoline | HCID 22624996 | 46% |
Reaction Steps
Using an analogous procedure to that described for the starting material in Example 1, 4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (400 mg) was reacted in the presence of catalytic potassium iodide with 3-chloromethylthiophene (Journal of the Chemical Society 1958, 4202) (168 mg) to give 4-(3-acetoxy-4-methylanilino)-6-methoxy-7-(3-thienylmethoxy)quinazoline (210 mg, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362336B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-bea83190cab9425fac1ad8e961591c7a |
| Source note | uspto-grants-2002_03 |