Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride → 7-Benzyloxy-4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxyquinazoline hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline hydrochloride | HCID 22030836 | — |
| 반응물 | 5-Amino-4-fluoro-2-methylphenyl Methoxyformate | HCID 22625046 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 7-Benzyloxy-4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxyquinazoline hydrochloride | HCID 22624930 | 87% |
반응 단계
A solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline hydrochloride (800 mg, 2.4 mmol), (prepared as described for the starting material in Example 1), and 2-fluoro-5-methoxycarbonyloxy-4-methylaniline (570 mg, 2.89 mmol) in isopropanol (20 ml) was refluxed for 2 hours. After cooling to ambient temperature, the solid was filtered, washed with isopropanol and dried under vacuum to give 7-benzyloxy-4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-6-methoxyquinazoline hydrochloride (1.0 g, 87%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06362336B1 |
| 출처 데이터셋 | uspto-grants-2002_03 |
| ORD ID | ord-6ef1f7dcb4074ac8bd64c219bd57a832 |
| 출처 메모 | uspto-grants-2002_03 |