HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 22624918, compound → HCID 22624886, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 22624918 | HCID 22624918 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22624886 | HCID 22624886 | 99.2% |
Reaction Steps
A solution of 1-[3-(tetrahydropyran-2-yloxy)propyl]-1,4-dihydro-4-pyridone (0.75 g, 3.16 mmol) in acetic acid (8 ml), THF (4 ml) and water (4 ml) was heated at 50° C. for 4 hours. The volatiles were removed by evaporation to give 1-(3-hydroxypropyl)-1,4-dihydro-4-pyridone (480 mg, 99%) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362336B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-5e3ea9978f5d41738341ed7063cba8f6 |
| Source note | uspto-grants-2002_03 |