HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 279544Generated: October 30, 2026
Thionyl Chloride → 4-Chloro-7-(4-pyridylmethoxy)quinazoline hydrochloride
https://huagongshe.com/reaction/279544
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-(4-Pyridylmethoxy)-3,4-dihydroquinazolin-4-one | HCID 135671181 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 4-Chloro-7-(4-pyridylmethoxy)quinazoline hydrochloride | HCID 22625079 | 98% |
Reaction Steps
A mixture of 7-(4-pyridylmethoxy)-3,4-dihydroquinazolin-4-one (320 mg, 1.26 mmol), DMF (1 drop) and thionyl chloride (10 ml) was heated at 60° C. for 1 hour. The volatiles were removed by evaporation, the residue was triturated with ether, collected by filtration, washed with ether and dried under vacuum to give 4-chloro-7-(4-pyridylmethoxy)quinazoline hydrochloride (435 mg, 98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06362336B1 |
|---|
| Source dataset | uspto-grants-2002_03 |
|---|
| ORD ID | ord-f0f1fe6fe73343df9a762aaf62dec0f1 |
|---|
| Source note | uspto-grants-2002_03 |
|---|
