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2-Acetamido-4-chloromethylthiazole → 7-((2-Acetamidothiazol-4-yl)methoxy)4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Acetamido-4-chloromethylthiazole | HCID 81963 | — |
| 反応物 | 4-(2-Fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride | HCID 135671179 | — |
| 生成物 | 7-((2-Acetamidothiazol-4-yl)methoxy)4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline | HCID 15886046 | 25.2% |
反応手順
Using an analogous procedure to that described in Example 27, 4-(2-fluoro-5-methoxycarbonyloxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (470 mg 1.14 mmol), (prepared as described for the starting material in Example 22), and 2-acetamido-4-chloromethylthiazole (381 mg, 1.68 mmol) were combined to give 7-((2-acetamidothiazol-4-yl)methoxy)-4-(2-fluoro-5-hydroxy-4-methylanilino)-6-methoxyquinazoline (135 mg, 25%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06362336B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-7198824a60df458f987d79be9057038c |
| 出典メモ | uspto-grants-2002_03 |