HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 279597Generated: November 1, 2026
Hydrochloric Acid → HCID 135671182, compound
https://huagongshe.com/reaction/279597
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 7-((2-Chloro-4-pyridyl)methoxy)-6-methoxy-4-phenoxyquinazoline | HCID 22624914 | — |
| Product | HCID 135671182 | HCID 135671182 | 76% |
Reaction Steps
A mixture of 7-((2-chloro-4-pyridyl)methoxy)-6-methoxy-4-phenoxyquinazoline (260 mg, 0.7 mmol) and 2M hydrochloric acid (15 ml) was heated at 85° C. for 2 hours. The mixture was allowed to cool and adjusted to pH6-7 with sodium hydrogen carbonate solution. The resulting precipitate was collected by filtration and dried to give 7-((2-chloro-4-pyridyl)methoxy)-6-methoxy-3,4-dihydroquinazolin-4-one (160 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06362336B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-548fae1c5341422b910d398b8c68b878 |
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| Source note | uspto-grants-2002_03 |
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