HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-(Chloromethyl)picolinonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-(Hydroxymethyl)pyridine-2-carbonitrile | HCID 10725391 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(Chloromethyl)picolinonitrile hydrochloride | HCID 22625068 | 86% |
Reaction Steps
A mixture of 2-cyano-4-hydroxymethylpyridine (0.51 g, 3.8 mmol) and thionyl chloride (0.6 ml) in toluene (20 ml) was stirred at room temperature for 1 hour. The volatiles were removed by evaporation and the residue azeotroped with toluene to give 4-chloromethyl-2-cyanopyridine hydrochloride (620 mg, 86%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362336B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-ceac2a3b37584987bdcf9123d5f184a5 |
| Source note | uspto-grants-2002_03 |