Sodium Acetate → Sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

15 g of the syn isomer of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid were dissolved at -15° C. in a solution of 5 g of sodium acetate in 100 ml of methanol and 3 g of activated carbon were added thereto. The solution was filtered and the filtrate was heated to 20° C. to obtain crystals of a methanol solvate of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylate identical to the product of Step A of Example 1.

Provenance & Evidence