HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 279663Generated: October 30, 2026
3-Aminophenol → 4-(3-Hydroxyanilino)-7-(2-(imidazol-1-yl)ethoxy)-6-methoxyquinazoline hydrochloride
https://huagongshe.com/reaction/279663
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Aminophenol | HCID 11568 | — |
| Reactant | 4-Chloro-6-methoxy-7-(2-(imidazol-1-yl)ethoxy)quinazoline | HCID 11141261 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(3-Hydroxyanilino)-7-(2-(imidazol-1-yl)ethoxy)-6-methoxyquinazoline hydrochloride | HCID 22625050 | 93% |
Reaction Steps
A mixture of 4-chloro-7-(2-(imidazol-1-yl)ethoxy)-6-methoxyquinazoline (49 mg, 0.16 mmol) and 3-hydroxyaniline (21 mg, 0.19 mmol) in isopropanol (3 ml) and isopropanolic hydrogen chloride (0.2 ml of a 5M solution) was stirred at 80° C. for 1 hour. The precipitated solid was collected by filtration, washed with isopropanol and ether and dried under vacuum to give 4-(3-hydroxyanilino)-7-(2-(imidazol-1-yl)ethoxy)-6-methoxyquinazoline hydrochloride (56 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06362336B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-01ee86cb9d0d459dbbf81e94a4c65a77 |
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| Source note | uspto-grants-2002_03 |
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