Sodium Acetate → Sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylate

HRID 27968Notes

Reaction equation

HRID 27968 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:29])[C:19]([C:23]3[N:24]=[C:25]([NH2:28])[S:26][CH:27]=3)=[N:20][O:21][CH3:22])[C:15](=[O:30])[N:10]2[C:11]=1[C:12]([OH:14])=[O:13])(=[O:3])[CH3:2].C([O-])(=O)C.[Na+:35]>O.C(O)C>[C:1]([O:4][CH2:5][C:6]1[CH2:7][S:8][C@@H:9]2[CH:16]([NH:17][C:18](=[O:29])[C:19]([C:23]3[N:24]=[C:25]([NH2:28])[S:26][CH:27]=3)=[N:20][O:21][CH3:22])[C:15](=[O:30])[N:10]2[C:11]=1[C:12]([O-:14])=[O:13])(=[O:3])[CH3:2].[Na+:35]

Participants

5

Reactant 2

HCID 517045Sodium AcetateHCID 1317115033-Acetoxymethyl 7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid

Product 1

HCID 131711736Sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylateYield 5.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

10 g of the syn isomer of 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme-4-carboxylic acid containing 7.2% of ethanol were added to a solution of 2 g of sodium acetate in 7.5 ml of water and 20 ml of absolute ethanol and the mixture was stirred for 15 minutes, was treated with 1.5 g of activated carbon and was filtered. The filter was washed twice with 5 ml of a 9-1 ethanol-water mixture and the filtrate was added dropwise over 50 minutes with stirring at room temperature to 80 ml of ethanol which caused precipitation of the sodium salt. The mixture was stirred for 2 hours at 0° C. and was vacuum filtered. The crystals were washed with ethanol and dried under reduced pressure to obtain 8.45 g of the crystalline D form of the syn isomer of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-ceph-3-eme- 4-carboxylate containing 5.7% of water.

Workup

  1. additionwas treated with 1.5 g of activated carbon
  2. filtrationwas filtered
  3. washThe filter was washed twice with 5 ml of a 9-1 ethanol-water mixture
  4. additionthe filtrate was added dropwise over 50 minutes
  5. stirringwith stirring at room temperature to 80 ml of ethanol which
  6. customprecipitation of the sodium salt
  7. stirringThe mixture was stirred for 2 hours at 0° C.
  8. filtrationfiltered
  9. washThe crystals were washed with ethanol
  10. customdried under reduced pressure

Sources & evidence

ORD record
ord-f412a63e11db42a0a34eba6d101a1409
Source dataset
uspto-grants-1980_09
Patent number
US04224371

Reaction notes

Loading…