HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → HCID 18714223, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Reactant | 1-Naphthalenepropanoic acid, α-amino-, methyl ester, hydrochloride (1:1), (αS)- | HCID 69976275 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | HCID 18714223 | HCID 18714223 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to β-(1-naphthyl)alanine methyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared via hydrolysis of the methyl ester using LiOH in THF/water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362341B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-f0b418039e604e0d884fd1838e295422 |
| Source note | uspto-grants-2002_03 |