HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → N-(Toluene-4sulfonyl)-L-prolyl-beta-(2-naphthyl)-L-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | methyl (2S)-2-amino-3-(naphthalen-2-yl)propanoate hydrochloride | HCID 56777259 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | N-(Toluene-4sulfonyl)-L-prolyl-beta-(2-naphthyl)-L-alanine | HCID 18714224 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to β-(2-naphthyl)-L-alanine methyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared via hydrolysis of the methyl ester using LiOH in THF/water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06362341B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-e969b53c132d433f8b3b70b2a601bda0 |
| Source note | uspto-grants-2002_03 |