N-tosyl-(s)-proline monohydrate → HCID 54522782, compound

HRID 279718Notes

Reaction equation

HRID 279718 reaction equation
O.[C:2]1([CH3:19])[CH:7]=[CH:6][C:5]([S:8]([N:11]2[CH2:18][CH2:17][CH2:16][C@H:12]2[C:13]([OH:15])=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.[CH:27]([O:30][C:31](=[O:41])[C@H:32]([CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[NH2:33])([CH3:29])[CH3:28]>>[CH:27]([O:30][C:31](=[O:41])[C@H:32]([CH2:34][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)[NH:33][C:13](=[O:15])[C@@H:12]1[CH2:16][CH2:17][CH2:18][N:11]1[S:8]([C:5]1[CH:4]=[CH:3][C:2]([CH3:19])=[CH:7][CH:6]=1)(=[O:9])=[O:10])([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 69463844N-tosyl-(s)-proline monohydrateHCID 69977640HCID 69977640, compound

Product 1

HCID 54522782HCID 54522782, compound

Procedure

N-(Toluene-4-sulfonyl)-L-proline hydrate was coupled to phenylalanine isopropyl ester trifluoroacetate using the procedure described in Method 3 to give the title compound as an oil.

Sources & evidence

ORD record
ord-e8a32bfe9a2945a59453f076ed5a68e7
Source dataset
uspto-grants-2002_03
Patent number
US06362341B1

Reaction notes

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