反应详情

(3S-trans)-2-Oxo-3-[[(phenylmethoxy)carbonyl]amino]-4-methyl-1-azetidinesulfonic acid, 8-hydroxyquinolinium salt (230 mg, 0.5 mmol; see Method IA) was dissolved in absolute ethanol (10 ml) and refluxed for 4 hours. Ethanol was removed in vacuo yielding a residue which was triturated with ethyl acetate (5×10 ml). From the combined extract, solvent was removed in vacuo affording a residue which was chromatographed on silica gel (Mallinckrodt CC-7). Elution with ethyl acetate yielded (3S-trans)-3-[[(phenylmethoxy)carbonyl]amino]-4-methyl-2-azetidinone (98 mg).

1. temperaturerefluxed for 4 hours
2. customEthanol was removed in vacuo
3. customyielding a residue which
4. customwas triturated with ethyl acetate (5×10 ml)
5. extractionFrom the combined extract
6. customsolvent was removed in vacuo
7. customaffording a residue which
8. customwas chromatographed on silica gel (Mallinckrodt CC-7)
9. washElution with ethyl acetate