反应详情

(3S)-2-Oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidinesulfonic acid, 8-hydroxyquinolinium salt (150 mg, 0.337 mmol) was added to acetonitrile (10 ml) and rapidly heated to reflux in a preheated oil bath. After refluxing for a total of 18 minutes, the mixture was cooled to room temperature, filtered through Celite, and solvent was removed in vacuo. The residue was extracted with an acetonitrile-ethyl acetate mixture and the extract chromatographed on a silica gel column (Mallinckrodt SilicAR CC-7). The desired product (31 mg) was eluted with a 5% acetonitrile:95% ethyl acetate mixture.

1. temperaturerapidly heated
2. temperatureto reflux in a preheated oil bath
3. temperatureAfter refluxing for a total of 18 minutes
4. filtrationfiltered through Celite, and solvent
5. customwas removed in vacuo
6. extractionThe residue was extracted with an acetonitrile-ethyl acetate mixture
7. customthe extract chromatographed on a silica gel column (Mallinckrodt SilicAR CC-7)
8. washThe desired product (31 mg) was eluted with a 5% acetonitrile