Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl thyroxinate hydrochloride | HCID 13911220 | — |
| Product | Thyroxine | HCID 5819 | — |
Reaction Steps
In 150 ml of dried tetrahydrofuran 1.65 g (0.002 mol) of thyroxine methyl ester hydrochloride was dissolved. To the resulting solution 300 μl (0.0021 mol) of triethyl amine and 200 mg. (0.0022 mol) of succinic anhydride were added. The mixture was stirred at 4° C. overnight to effect reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04587102 |
|---|
| Source dataset | uspto-grants-1986_05 |
|---|
| ORD ID | ord-d6e33fbb8e70494a89adc8bd3b8100b1 |
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| Source note | uspto-grants-1986_05 |
|---|
