HRID279826

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7918

Acetic anhydride

C4H6O3

结构：CC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

HCID13131727

(6α,11β)-17-(Acetyloxy)-11,21-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

C24H32O6

PRODUCTS

生成物

结构：CC(=O)OCC(=O)[C@@]1(OC(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C

HCID13131729

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A solution of 1.0 g of 17-acetoxy-11β,21-dihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione in 10 ml of pyridine is stirred with 5 ml of acetic anhydride for one hour at 0° C. Then the mixture is poured on an ice water-sodium chloride solution; the precipitate is filtered off and purified by crystallization from acetone/hexane, thus isolating 810 mg of 17,21-diacetoxy-11β-hydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, mp 216° C.

WORKUP

后处理

filtrationthe precipitate is filtered off
custompurified by crystallization from acetone/hexane